Clinical Trial Finder

Hundreds of clinical trials are rolled out around the world monthly, and many of them are designed to specifically uncover and manage the medical needs of people with sickle cell disease and trait. We keep an updated list of these global studies here, so you don’t have to go searching for them. There might be active study recruitment and enrollment happening at a site near you. Explore the list below to see the different types of studies, and use the navigation options on the left to get as specific as you would like.

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Brain Structure and Neurocognitive Development in Sickle Cell Disease; a Longitudinal Cohort Study (BRICK Study)

Sickle cell disease (SCD) is an autosomal recessive red blood cell blood disorder.

Locations

182 Netherlands sites

Age

6 Years - 25 Years

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The Cognitive-Remediation of Executive and Adaptive Deficits in Youth (C-READY) Intervention: A Randomized Controlled Trial for Adolescents With Sickle Cell Disease to Prepare for Transition of Care

Randomized Controlled Trial (RTC) testing the efficacy of a telehealth adaptation of the Cognitive-Remediation of Executive and Adaptive Deficits in Youth (C-READY) intervention to prepare adolescents with sickle cell disease for transition of care.

Locations

88 United States sites

Age

10 Years - 18 Years

Phase

Phase 2

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Sickle Cell Improvement: Enhancing Care in the Emergency Department

Sickle cell disease (SCD) is an inherited blood disorder affecting approximately 36,000 children in the United States, approximately 90% of whom are Black.

Locations

93 United States sites

Age

< 18 Years

Phase

Not Applicable

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Autologous Testicular Tissue Transplantation for Fertility Restoration

Freezing testicular tissue of prepubertal boys is a method for preserving spermatogonial stem cells (SSCs) in case of imminent gonadotoxic treatment during childhood.

Locations

84 Belgium sites

Age

18 Years - 50 Years

Phase

Not Applicable

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Primary Prevention of Stroke in Children With Sickle Cell Anaemia in Nigeria: Community vs Teaching Hospital

The overall goal of this feasibility study is to establish a standard of care stroke prevention program for children with sickle cell anemia in a community hospital by task shifting stroke detection and transcranial Doppler ultrasound screening to nurses.

Locations

74 Nigeria sites

Age

2 Years - 16 Years

Phase

Not Applicable

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Observational Study to Deeply Phenotype Major Organs in Sickle Cell Disease After Curative Therapies

Background: People with sickle cell disease (SCD) have problems with their heart, brain, kidneys, liver, and lungs as they age.

Locations

376 United States sites

Age

18 Years - 100 Years

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Addition of JSP191 (C-kit Antibody) to Non-myeloablative Hematopoietic Cell Transplantation For Sickle Cell Disease and Beta-Thalassemia

Background: Sickle cell disease (SCD) is an inherited disorder of the blood.

Locations

82 United States sites

Age

4 Years - 100 Years

Phase

Phase 1/Phase 2

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Study of Erythrocyte Parameters and Hypercoagulability in Sickle Cell Disease

Sickle cell disease (SCD) is an inherited haemoglobinopathy disorder caused by mutations in HBB gene with amino-acid substitution on β globin chain.

Locations

81 France site

Age

> 18 Years

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Quality of Life Response to Pilates Physical Activity in Sickle Cell Disease

Sickle cell anemia (SCA) is a life-threatening hereditary hemoglobinopathy characterized by hemoglobin (Hb) polymerization that affects many people worldwide.

Locations

82 Egypt sites

Age

18 Years - 55 Years

Phase

Not Applicable

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CHOICES for Sickle Cell Reproductive Health: Randomized Clinical Trial (RCT) of a Preconception Intervention Model for a Single Gene Disorder

The study will use web-based data collection (SCKnowIQ) and intervention delivery strategies enhanced by nudges and tailored boosters in a sample of 430 adult men and women, aged 18-45 yr with SCD (Sickle Cell Disease) or SCT (Sickle Cell Trait), at-risk, and planning within 2 years to have a child free of SCD.

Locations

157 United States sites

Age

18 Years - 45 Years

Phase

Not Applicable

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