Clinical Trial Finder

Hundreds of clinical trials are rolled out around the world monthly, and many of them are designed to specifically uncover and manage the medical needs of people with sickle cell disease and trait. We keep an updated list of these global studies here, so you don’t have to go searching for them. There might be active study recruitment and enrollment happening at a site near you. Explore the list below to see the different types of studies, and use the navigation options on the left to get as specific as you would like.

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CHOICES for Sickle Cell Reproductive Health: Randomized Clinical Trial (RCT) of a Preconception Intervention Model for a Single Gene Disorder

The study will use web-based data collection (SCKnowIQ) and intervention delivery strategies enhanced by nudges and tailored boosters in a sample of 430 adult men and women, aged 18-45 yr with SCD (Sickle Cell Disease) or SCT (Sickle Cell Trait), at-risk, and planning within 2 years to have a child free of SCD.

Locations

173 United States sites

Age

18 Years - 45 Years

Phase

Not Applicable

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A Phase 3 Study to Evaluate the Safety and Efficacy of a Single Dose of CTX001 in Pediatric Subjects With Severe Sickle Cell Disease

This is a single-dose, open-label study in pediatric participants with severe SCD and hydroxyurea (HU) failure or intolerance.

Locations

295 United States sites

82 Italy sites

77 United Kingdom sites

67 Germany sites

Age

2 Years - 11 Years

Phase

Phase 3

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Observational Study to Deeply Phenotype Major Organs in Sickle Cell Disease After Curative Therapies

Background: People with sickle cell disease (SCD) have problems with their heart, brain, kidneys, liver, and lungs as they age.

Locations

416 United States sites

Age

18 Years - 100 Years

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Addition of JSP191 (C-kit Antibody) to Non-myeloablative Hematopoietic Cell Transplantation For Sickle Cell Disease and Beta-Thalassemia

Background: Sickle cell disease (SCD) is an inherited disorder of the blood.

Locations

91 United States site

Age

4 Years - 100 Years

Phase

Phase 1/Phase 2

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Revamping Exercise Assessments in Child Health (Project REACH)

This study is a cooperative investigation funded by the NIH.

Locations

100 United States sites

Age

10 Years - 17 Years

Phase

Not Applicable

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Study of Erythrocyte Parameters and Hypercoagulability in Sickle Cell Disease

Sickle cell disease (SCD) is an inherited haemoglobinopathy disorder caused by mutations in HBB gene with amino-acid substitution on β globin chain.

Locations

87 France sites

Age

> 18 Years

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Universal Genomic Newborn Screening in the Wallonia-Brussels Federation: Baby Detect

Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions.

Locations

89 Belgium sites

Age

< 28 Days Years

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Quality of Life Response to Pilates Physical Activity in Sickle Cell Disease

Sickle cell anemia (SCA) is a life-threatening hereditary hemoglobinopathy characterized by hemoglobin (Hb) polymerization that affects many people worldwide.

Locations

89 Egypt sites

Age

18 Years - 55 Years

Phase

Not Applicable

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Telemedicine for Pediatric Sickle Cell Patients in Medically Underserved Areas

The purpose of this study is to learn more about how the use of two different types of telemedicine (distance medical care) can address barriers to receiving comprehensive sickle cell care, and whether care can be improved.

Locations

80 United States sites

Age

> 16 Years

Phase

Not Applicable

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A Phase 1/2 Study to Evaluate the Safety and Efficacy of a Single Dose of Autologous Clustered Regularly Interspaced Short Palindromic Repeats Gene-edited CD34+ Human Hematopoietic Stem and Progenitor Cells (EDIT-301) in Subjects With Severe Sickle Cell Disease

The purpose of this study is to evaluate the efficacy, safety and tolerability of treatment with EDIT-301 in adult and adolescent participants with severe sickle cell disease (SCD).

Locations

1577 United States sites

249 Canada sites

Age

12 Years - 50 Years

Phase

Phase 1/Phase 2

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